在急性心力衰竭中使用抗精神病药物和食症风险:一项前性队列研究
Haruyo Matsuo1, Yoshihiro Yoshimura2, Yuichi Maeno3
1Department of Nursing, Kagoshima Medical Association Hospital, 7-1 Kamoikeshinmachi, Kagoshima-Country, Kagoshima, 890-0064, Japan. minipink21@gmail.com.
Heart and vessels
|September 25, 2025
概括
在急性心力衰竭患者中使用抗精神病药物显著增加了吞障碍 (吞困难) 的风险. 这项研究强调了在这个脆弱人群中对吞的特定影响,而不是整体的身体功能.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 众所周知,抗精神病药物会引起食症.
- 抗精神病药对急性心力衰竭 (AHF) 患者的吞和身体功能的影响尚不清楚.
研究的目的:
- 在住院的AHF患者中调查抗精神病药物使用和食障碍之间的关联.
- 检查抗精神病药物对AHF患者身体功能的影响.
主要方法:
- 对325名住院的AHF患者进行前性队列研究.
- 使用食物摄入水平尺度 (FILS) 评估消化不良,使用巴特尔指数评估身体功能.
- 使用多重回归,逻辑回归和考克斯比例危险模型,调整混因素.
主要成果:
- 抗精神病药物使用者 (10.5%的队列) 在出院时出现食障碍的几率明显更高 (OR=7.724,p<0.001).
- 抗精神病药物的使用与住院期间失足症发病率增加有关 (HR=1.635,p=0.049).
- 在使用抗精神病药物和出院时的巴特尔指数 (p=0.658) 之间没有发现显著的关联.
结论:
- 在AHF患者中使用抗精神病药物与明显增加的消化障碍风险密切相关.
- 这些发现表明,抗精神病药对AHF患者的吞功能有特定的有害影响.
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