肝脏和大脑与衰老相关的衰退被精致饮食消费所加速
Franziska Kromm1, Haktan Övül Bozkir1, Annette Brandt1
1Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Josef-Holaubek-Platz 2 (UZA II), Vienna, 1090, Austria.
GeroScience
|September 25, 2025
概括
高度加工的饮食加速老化,导致认知和肝脏衰退. 在这项研究中,纤维丰富减缓了认知衰老,但没有预防其他与年龄有关的健康问题.
科学领域:
- 营养科学 营养科学
- 衰老研究研究 衰老研究
- 代谢健康 代谢健康
背景情况:
- 超加工食品含量高的饮食与疾病的发展有关.
- 动物的精制饮食与代谢疾病有关.
- 老龄化涉及健康的下降,包括认知和代谢障碍.
研究的目的:
- 为了研究精炼饮食对小鼠衰老的影响.
- 评估精制饮食中纤维丰富对与衰老相关的健康衰退的影响.
- 评估认知功能,葡萄糖代谢和器官健康标志物.
主要方法:
- 使用雄性C57BL/6J小鼠进行了两项实验.
- 给小鼠的是标准的或精致的饮食.
- 纤维丰富 (麦β-葡萄糖或纤维素) 在老年小鼠中进行了测试,这些小鼠有肠道功能障碍.
主要成果:
- 精致的饮食诱导加速衰老标志物,认知能力下降,肝脏问题和葡萄糖代谢受损.
- 这些影响与肠道微生物群的改变和内毒素水平的增加有关.
- 纤维丰富减缓了认知衰退,但没有改善肝脏健康或胰岛素抵抗.
结论:
- 精致的饮食加速老化相关的老鼠衰退,影响认知和新陈代谢.
- 精制饮食中的纤维强化可以缓解认知衰老.
- 纤维丰富可能无法完全抵消精制饮食在衰老过程中对其他器官的有害影响.
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