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Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
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Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
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Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
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The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
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用于最终用户验证可变形剂量积累不确定性建模工具的方法.

John Kipritidis1, Alexandra Quinn1, Tomasz Morgas2

  • 1Department of Radiation Oncology, Northern Sydney Cancer Center, Sydney, Australia.

Medical physics
|September 26, 2025
PubMed
概括

本研究引入了可变形剂量积累 (DDA) 不确定性模型的临床验证方法,这对于适应性放射治疗至关重要. 拟议的序列确保了可靠的DDA不确定性工具对治疗决策的性能.

关键词:
适应性治疗是一种适应性治疗.可变形图像的注册 变形图像的注册剂量累积剂量的累积.

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科学领域:

  • 医学物理 医学物理
  • 辐射疗法 辐射疗法
  • 图像指导 图像指导

背景情况:

  • 可变形剂量积累 (DDA) 不确定性模型对于通过量化可变形图像记录 (DIR) 错误来为放射治疗中的治疗决策提供信息至关重要.
  • 目前对于临床医生在临床环境中验证这些DDA不确定性模型的指导是有限的.

研究的目的:

  • 为DDA不确定性建模工具提出一个标准化的最终用户验证序列,作为一个验收测试.
  • 利用现有的患者数据和临床治疗计划系统 (TPS) 来评估DDA的不确定性工具.

主要方法:

  • 建议使用单个"固定"图像和"移动"图像的验证序列,模拟TPS中的分数DIR.
  • 来自DDA不确定性工具的输出,包括空间和剂量不确定性,将重新导入TPS进行交叉检查.
  • 评估涉及视觉和半定量评估 (基于点,基于DVH) 使用标准工具和供应商方程,考虑不同的DIR质量.

主要成果:

  • 验证序列在使用临床膀病例的非临床工具上进行了证明.
  • 在空间不确定性的情况下,在2个voxel内达成协议,在剂量不确定性的情况下,达成最多5%的处方剂量.
  • 在具有可信变形和稳定的剂量梯度 (<5%/voxel) 的区域中证明可靠性.

结论:

  • 随着DDA变得越来越普遍,DDA不确定性工具对适应性放射治疗越来越重要.
  • 这项工作通过使用随时可用的临床工具正式化了最终用户验证过程.
  • 确保可靠的DDA不确定性模型性能,以支持适应性治疗决策.