乳母牛的母乳和牛奶中的干细胞的纵向变化
Laurence Finot1, Marion Boutinaud1, Hélène Quesnel1
1PEGASE, INRAE, Institut Agro Rennes-Angers, Saint Gilles, France.
The Journal of dairy research
|September 26, 2025
概括
奶牛胆汁含有乳腺上皮细胞,介质细胞和造血细胞类干细胞,主要是在分娩后的头几个小时. 这些干细胞可能会转移到新生儿身上,并有可能融入他们的组织.
科学领域:
- 兽医科学 兽医科学 兽医科学
- 干细胞生物学 干细胞生物学
- 哺乳生理学 哺乳生理学
背景情况:
- 大奶粉和牛奶含有各种细胞类型,包括干细胞.
- 了解早期哺乳期的干细胞种群对于新生儿发育至关重要.
- 牛乳腺分泌物中干细胞的存在和动力学尚未完全表征.
研究的目的:
- 为了识别和量化乳牛牛乳和牛奶中的不同类干细胞种群.
- 为了确定这些干细胞的度和变化,从分娩到产后第一周.
- 研究这些细胞在新生儿发育中的潜在作用.
主要方法:
- 从荷尔斯坦牛产后 (d 0-7) 收集了乳腺分泌物.
- 细胞使用流细胞计与特定的干细胞标记物 (CD49f,CD24,CD34,CD105,CD90,CD29,CD45,CD117) 进行分析.
- 总和可活细胞度随着时间的推移被量化.
主要成果:
- 最高的总和可活细胞度是在产卵后6小时内收集的乳酪中发现的.
- 乳腺上皮干细胞 (CD49f+CD24+) 从分娩时的0.9%降至12小时后的0.1%.
- 中介细胞类干细胞 (CD34-CD105+CD90+CD29+) 最初相对不变,然后减少,而造血细胞类干细胞 (CD45-CD34+CD117+CD90+) 仅在分娩时存在.
结论:
- 所有研究的干细胞类型中,只有在早期结母乳 (产后第一小时) 中发现了大量的干细胞类型.
- 新生小牛的透性肠可能允许转移和整合这些结石干细胞.
- 这突显了在牛中从母细胞转移到后代的潜在机制.
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