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Updated: Jan 16, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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硫非尼尔亚齐里丁作为瘤转录因子MYC的立体选择性共价破坏稳定降解剂

Hannah T Rosen1,2,3,4, Kelvin Li1,4, Christian E Stieger1,2,3,4

  • 1Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.

Angewandte Chemie (International ed. in English)
|September 26, 2025
PubMed
概括

研究人员开发了一种新型的共价接体,通过利用其无序区域来向并降解致癌MYC蛋白. 这一突破为准以前"无法治疗"的癌症驱动因素 (如MYC) 提供了一种新的策略.

关键词:
基于活动的蛋白质概况.化学蛋白质组学 化学蛋白质组学 化学蛋白质组学一个共价的共价物.半氨酸 (cysteine) 是一种蛋白质.我的世界 MYC硫非尼尔亚齐里丁是一种硫非尼尔亚齐里丁.有针对性的蛋白质降解降解.

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