代谢功能障碍相关的脂肪性肝病在南亚种族的流行病学:系统性审查和元分析
Michael James1, Melanie Smuk2, Naheeda Rahman1
1Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.
Journal of gastroenterology and hepatology
|September 26, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在南亚人中非常普遍,影响超过三分之一的人口. 晚期纤维化也令人担忧,强调需要对这一族群进行进一步研究.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 南亚人群对代谢综合征的倾向较高.
- 在这个人口群体中,代谢功能障碍相关的脂肪性肝病 (MASLD) 的流行病学尚未得到充分确立.
- 这项研究解决了关于南亚人中MASLD患病率和严重程度的知识差距.
研究的目的:
- 系统地审查和对南亚种族中MASLD的流行情况进行元分析.
- 在这个人群中评估MASLD的横截面严重程度,包括晚期纤维化.
- 评估与南亚人MASLD相关的临床相关终点.
主要方法:
- 2002年1月至2023年11月期间发表的研究的系统审查和元分析.
- 在主要的数据库中进行了搜索:PubMed,Embase,Ovid和Cochrane.
- 随机效应元分析被用于汇集流行率和比例数据.
主要成果:
- 包括62项涉及40745名参与者的研究,主要来自印度.
- 总体而言,MASLD的综合患病率为34.7%,在城市环境 (47.1%) 和2型糖尿病患者 (60.0%) 中显著更高.
- 14.0%的参与者患有晚期纤维化 (≥F3);由于终点异质性,对临床结果的元分析是不可行的.
结论:
- 在南亚族裔中,MASLD的流行率特别高.
- 晚期纤维化个体的比例可能超过多民族人口中的比例.
- 高质量的纵向研究对于充分阐明这一队列中MASLD的流行病学至关重要.
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