iTr35细胞:一种新的免疫调节子集,涉及类风湿性关节炎骨损失和临床影响
Yuxuan Li1, Mingxin An2, Lutian Yao3
1Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, China.
Annals of medicine
|September 26, 2025
概括
在类风湿性关节炎 (RA) 患者中,可诱导IL-35产生调节性T细胞 (iTr35) 减少,与较低的骨矿物质密度相关. 这表明iTr35细胞可以防止RA相关的骨损失.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 骨质免疫学 骨质免疫学
背景情况:
- 类风湿性关节炎 (RA) 是一种自身免疫性疾病,导致慢性炎症和骨破坏.
- 虽然已知调节性T (Treg) 细胞可以抑制骨损失,但诱导IL-35产生调节性T细胞 (iTr35) 在RA中的作用尚不清楚.
研究的目的:
- 在RA患者中研究iTr35细胞的频率.
- 评估iTr35细胞与骨矿物质密度 (BMD) 和RA骨周转标记物之间的关联.
主要方法:
- 从34名RA患者和34名健康对照组中收集了外周血液单核细胞 (PBMC).
- 使用流细胞计量量化 iTr35,Treg,Teff 和原始 CD4+ T 细胞.
- 测量了BMD和血清骨周转标记物 (TRAP5b,CTX-I,骨质卡尔).
主要成果:
- 关节炎患者的iTr35和Treg细胞频率降低,Teff细胞增加.
- iTr35水平与腰椎和大腿部部BMD负相关.
- iTr35频率与骨再吸收标志物 (TRAP5b,CTX-I) 相反相关,与骨形成标志物 (骨素) 相反相关.
结论:
- iTr35细胞代表了一种新型的免疫调节子集,有可能保护RA的骨质损失.
- iTr35细胞在骨质免疫调节中发挥着重要作用.
- iTr35可能具有预防自身免疫性疾病骨损伤的治疗潜力.
相关概念视频
T Cell Types and Functions
2.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.2K
Osteoclasts in Bone Remodeling
3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Inflammatory Response
16.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.0K


