在凉爽的条件下摄入mirabegron的发热效应
Felipe Gorini Pereira1, Caleb T Ryan1, Spencer Miller1
1Department of Kinesiology, School of Public Health, Indiana University, Bloomington, IN, United States.
Frontiers in physiology
|September 26, 2025
概括
米拉贝格伦是一种β3上腺素受体激动剂,在凉爽的环境中增加能量消耗和棕色脂肪组织 (BAT) 激活. 这表明,即使不暴露在寒冷中,mirabegron也可以增强热生成.
科学领域:
- 代谢和内分泌学
- 热生成研究 热生成研究
- 上腺体受体对抗性反应
背景情况:
- 棕色脂肪组织 (BAT) 是一个关键的热生成器官.
- 米拉贝格伦激活β3-上腺素受体,这是一个已知的BAT刺激剂.
- 在凉爽,但不冷的环境中,mirabegron对热生成的影响是未知的.
研究的目的:
- 调查米拉贝格朗的摄入是否会增加能量消耗.
- 为了确定mirabegron是否在凉爽的环境中激活棕色脂肪组织 (BAT).
- 为了测试mirabegron的发热效应是否依赖于剂量.
主要方法:
- 在一项双盲随机研究中,健康的成年人摄入了mirabegron (100-200毫克) 或安慰剂 (PLA).
- 使用全身间接热量计在20°C时测量能量消耗.
- 评估棕色脂肪组织 (BAT) 活动使用红外热学来测量关节骨上皮肤温度.
主要成果:
- 与安慰剂相比,Mirabegron摄入显著增加了累积的能量消耗.
- 在服用100毫克和150毫克米拉贝格朗剂量后,肌肤上关节温度,表明BAT活性,升高.
- 不同的mirabegron剂量之间没有观察到能源消耗或BAT激活的显著差异.
结论:
- 摄入Mirabegron可以在凉爽的环境中增强热生成.
- 通过mirabegron激活β3-上腺体受体,刺激棕色脂肪组织 (BAT).
- 米拉贝格朗的热能效应在凉爽的条件下显而易见,而不仅仅是寒冷的条件.
相关概念视频
Thermoregulation
2.3K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
2.3K
Decreased Body Temperature
1.0K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.0K
Increased Body Temperature
6.4K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
6.4K
Factors Affecting Body Temperature
8.6K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may include:
Factors may include:
8.6K
Cholinergic Antagonists: Pharmacological Actions
1.6K
Antimuscarinic drugs block muscarinic receptors in multiple systems, including the gut, eye, smooth muscles, respiratory tract, cardiovascular, and central nervous systems. They produce similar effects with varying selectivity depending on the specific agent and tissue. Here are the key pharmacological actions of antimuscarinics:
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
1.6K
Assessing Body Temperature - Rectal
11.5K
Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
11.5K


