肠道微生物群治疗慢性病的治疗方法
Chunguang Liu1, Junhong Wang2, Lei Lei1
1Department of Nephrology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China.
Frontiers in immunology
|September 26, 2025
概括
慢性病 (CKD) 与肠道失调有关. 通过益生菌,饮食或便微生物群移植 (FMT) 调节肠道微生物群显示了对CKD管理的治疗潜力.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
背景情况:
- 慢性病 (CKD) 影响全球13%的人口,并且越来越多地与肠道微生物群失调有关.
- 在CKD中,肠道功能失调是由尿素毒素,代谢变化和饮食驱动的,影响疾病的进展.
研究的目的:
- 审查肠道微生物群调制作为缓解CKD症状的治疗策略.
- 探索针对CKD肠道微生物群组成和功能的干预措施.
主要方法:
- 审查现有的关于益生菌 (例如,耐药粉),饮食调整 (低蛋白,无质),便微生物群移植 (FMT),协生菌,益生菌和其他干预措施的文献.
- 分析研究研究这些干预措施对尿素毒素,炎症,微生物多样性,脏生物标志物和临床结果的影响.
- 考虑新兴的策略,如菌体疗法和人工智能驱动的多组学.
主要成果:
- 益生菌和饮食变化在减少尿素毒素和炎症以及改善脏生物标志物方面表现有前途.
- 便微生物群移植 (FMT) 稳定了肌素,并有利地转移了肠道微生物群.
- 益生菌,共生菌和其他经过测试的干预措施存在可变的疗效和局限性,因果关系和方法异质性不清楚.
结论:
- 肠道微生物群调制为CKD提供治疗潜力,但临床转换需要严格的试验来解决不一致性并建立机械联系.
- 未来的研究应该专注于纵向研究,母体肠道微生物群的优化,以及基于精度的CKD预防和管理的个性化方法.
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