短期和长期抑制新型病原体对宿主群体的抑制
1Dept of Biological Sciences, University of Idaho, Moscow, ID USA.
bioRxiv : the preprint server for biology
|September 26, 2025
概括
新的病原体可以导致人口减少,但像恒温和母体抗体这样的因素可以改变这一点. 这些元素影响宿主群体抑制,即使没有病原体进化.
科学领域:
- 流行病学 流行病学
- 人口动态 人口动态
- 疾病生态学 疾病生态学
背景情况:
- 病原体诱导的宿主群体抑制通常伴随着反弹和病毒性降低.
- 这种调节被认为会随着病原体的传染性 (R0) 和毒性而增加.
研究的目的:
- 探索恒温,母体抗体和年龄相关死亡率如何影响短期和长期宿主群体抑制.
- 在没有遗传进化的情况下调查病原体-宿主动态.
主要方法:
- 使用了简单的流行病学模型.
- 分析了密度依赖人口调节 (恒温),孕产妇抗体和年龄依赖死亡率的影响.
主要成果:
- 快速的平衡缓解了长期的人口抑制; 弱的平衡可以增加特有抑制.
- 减弱而不是阻止感染的母体抗体减少了宿主群体的抑制.
- 在年轻宿主中,较低的疾病严重程度也导致抑制减少,可能降低R0和无进化病毒性.
结论:
- 新病原体对宿主群体的抑制是复杂的,并且对病原体进化之外的因素敏感.
- 恒温,母体抗体和特定年龄的疾病严重程度显著调节了流行病的结果.
- 需要一个细微的观点,因为即使没有进化,病原体与宿主相互作用也会随着时间的推移导致毒性降低.
更多相关视频
11:12Protocols for Investigating the Host-tissue Distribution, Transmission-mode, and Effect on the Host Fitness of a Densovirus in the Cotton Bollworm
Published on: April 12, 2017
9.0K
08:38Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
Published on: February 22, 2019
6.3K
相关概念视频
Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Infection
11.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.9K
Stages of Infection
64.9K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.9K
Immune Response Against Viral Pathogens
1.8K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.8K
Gene Regulation in Microbial Communities: Quorum Sensing
524
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
524
Transduction
1.3K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
1.3K
