在核心和带听力皮层的声音包裹编码中的区域间和层间差异.
Chase A Mackey1, Yoshinao Kajikawa1,2
1Nathan Kline Institute for Psychiatric Research, Center for Biomedical Imaging and Neuromodulation, Orangeburg, NY 10962.
bioRxiv : the preprint server for biology
|September 26, 2025
概括
非人类灵长类动物 (NHP) 的神经回路显示了振幅调制 (AM) 编码在听觉皮层中的变化. 左半球的增强时编码源自上粒状层.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 振幅调制 (AM) 编码对于复杂的声音感知至关重要.
- 听觉路径显示AM时间精度的层次下降.
- 与人类和非人类灵长类动物 (NHP) 的右半球相比,左半球表现出增强的时间编码.
研究的目的:
- 调查NHP听觉皮层 (AC) 中的皮层层和半球的AM编码.
- 确定AM编码转换背后的电路机制.
- 描述核心和带AC中的AM编码.
主要方法:
- 使用线性阵列多电极记录了在清醒的NHP中记录的电生理活动.
- 呈现的AM噪声和点击列车跨越皮质层.
- 分析了AM编码作为皮质层和半球的函数.
主要成果:
- 核心交流对所有AM频率 (1.6-200 Hz) 进行了高精度 (>90%) 的编码.
- 带交流编码了较低的AM频率 (1.6-25 Hz).
- 颗粒和细粒层显示了增强的AM编码.
- 左半球显示AM编码增强,特别是在supragranular层.
结论:
- 在第三级听力皮层 (听力皮带) 中仍然存在显著的AM时代编码.
- 特定层次的半球差异表明左半球在时间编码中占主导地位的超细粒原点.
- NHP模型阐明了AM编码转换的电路机制.
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