在接受心脏手术的患者手术压力期间的代谢轨迹
Dohyun Ku1, Jackson Bartelt2, Jenna Feeley2,3
1H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA.
bioRxiv : the preprint server for biology
|September 26, 2025
概括
手术患者的压力高血糖症 (SH) 涉及手术前后明显的代谢转变. 了解这些代谢变化可以帮助预测和管理SH,改善手术结果.
科学领域:
- 生物化学 生物化学
- 代谢学 代谢学 代谢学
- 手术生理学 手术生理学
背景情况:
- 压力高血糖症 (SH) 与不良的手术结果有关.
- 在SH期间的代谢变化尚未完全理解.
研究的目的:
- 在接受心脏手术的非糖尿病成年人中分析纵向的代谢变化.
- 为了确定与外科手术期间的SH相关的代谢途径.
主要方法:
- 纵向取血样 (基线,2小时,24-48小时,手术后72-96小时).
- 高分辨率代谢量 (LC-MS) 集成与持续的葡萄糖监测和生物标志物.
- 机器学习模型用于SH预测.
主要成果:
- 手术前的SH易感性与胆汁酸,肉氨酸穿和脂肪酸氧化途径有关.
- 术后的SH与C21类固醇激素,甘油脂和陶胺代谢有关.
- 在SH患者中,炎症标志物 (hs-CRP, uPAR) 较高.
- 代谢特征预测SH与AUC为0.86.6.
结论:
- 截然不同的术前和术后代谢轨迹是SH的特征.
- SH既涉及已知的失糖症,也涉及压力诱导的代谢途径.
- 需要进一步验证以评估临床影响.
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