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从MASLD到MASH的进展中的代谢,脂质和肠道激素变化
Jaclyn A Rivas1, Alexandria C Murphy2, Praveena Prasad2
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico Health Sciences, Albuquerque, NM 87131, USA.
bioRxiv : the preprint server for biology
|September 26, 2025
概括
代谢功能障碍相关的性肝病 (MASLD) 进展为MASH,肠肝轴荷尔蒙发生变化,胆酸增加. 氨酸可能会在MASH中驱动纤维化,这表明新的治疗点.
科学领域:
- *肝病学和代谢疾病研究.
- *胃肠道学和肠道微生物群的相互作用.
- * 肝病进展的分子和细胞生物学.
背景情况:
- *代谢功能障碍相关的性肝病 (MASLD) 和代谢功能障碍相关的性肝炎 (MASH) 是不同的,渐进性的肝病.
- *理解从MASLD过渡到MASH需要调查代谢和荷尔蒙变化.
- *肠肝轴在代谢性肝病中起着至关重要的作用.
研究的目的:
- * 调查从MASLD到MASH的进展过程中的代谢和激素变化.
- * 确定肝脏和肠道中关键的分子变化.
- * 探索肠内分泌激素和血清素在MASH发育和纤维化中的作用.
主要方法:
- * 诱导C57BL/6NTac小鼠使用高脂肪饮食的MASLD和MASH.
- *利用了肝脏,结肠和便样本上的代谢量和脂质量.
- *量化了血激素和细胞因子;对血和纤维素进行了免疫光检测.
主要成果:
- * 在MASLD和MASH小鼠的肝脏,结肠和便中观察到胆酸的增加.
- * MASLD小鼠显示GLP-1,GIP和PYY的升高;MASH小鼠没有显示这些变化.
- *MASH肝脏增加了血清素 (5-HT) 和纤维素,观察到的局部化表明纤维化中的作用.
结论:
- *这项研究揭示了从MASLD到MASH的逐渐代谢和荷尔蒙变化.
- * 胆酸和差异性肠内分泌激素反应突显了肠肝轴的复杂性.
- * 内分泌激素和血清激素显示出MASH和肝纤维化治疗点的潜力.
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