共享的条状神经元表现出内部和外部驱动的行动的特定背景动态
Jan L Klee1,2, Sulekh Fernando-Peiris1,3,2, Sahil Suresh1,4
1Department of Psychiatry and Neuroscience, New York University Grossman School of Medicine, New York, NY 10016, USA.
bioRxiv : the preprint server for biology
|September 26, 2025
概括
大脑使用共享的神经群体来灵活启动运动,无论是外部引发的还是内部驱动的. 神经动力学在这些人群中发生了变化,揭示了用于运动控制的文本通用性条形码.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 计算神经科学是一种神经科学.
背景情况:
- 运动启动可以是外部指导或内部驱动的,其中可能涉及不同的神经机制.
- 像帕金森病这样的疾病会对这些运动模式产生不同的影响,这凸显了了解它们潜在的神经基础的必要性.
- 目前尚不清楚专用电路或共享电路中的可适应动态是否支持灵活的运动启动.
研究的目的:
- 研究大脑如何灵活地支持内部和外部触发的运动.
- 区分专业化电路与共享的神经元群体之间的区别,不同动作模式的动态变化.
- 阐明在内部和外部启动的动作期间,背侧条纹体内的神经动态.
主要方法:
- 在执行杆按压任务的小鼠的背侧条纹体中进行两光子成像.
- 在自发 (内在驱动) 动作过程中的神经活动与提示引发 (外部触发) 动作之间的比较.
- 无监督的集群分析以确定神经元子群及其调制模式.
主要成果:
- 在提示,运动或后动作期间调节的识别的神经元子群.
- 证明相同的神经元在自发和被指导的环境中都被调整为运动启动.
- 揭示了神经群体动态在运动开始之前在不同的"上下文"和"行动"子空间中演变.
- 显示了多巴胺D1和D2受体表达脊状投影神经元的贡献,D1-SPN在感官刺激呈现期间更活跃.
结论:
- 背景动态塑造神经活动在共享的运动编码群体在条形体.
- 一个文本通用化的条形码支持灵活的运动启动,由内部和外部因素驱动.
- 这些发现提供了关于运动灵活性神经基础的见解,以及在运动障碍中被破坏的潜在机制.
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