早期的肠道微生物和代谢变化反映在便的一致性-一个肠道过渡时间代理
Anna-Katariina Aatsinki1,2, Matilda Kråkström3, Katja Salonen3
1Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
bioRxiv : the preprint server for biology
|September 26, 2025
概括
母乳养对婴儿便的一致性和含水量有很大影响. 微生物代谢物,如胆酸胺酸和短链脂肪酸 (SCFA) 也在婴儿肠道健康中发挥关键作用.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 儿科胃肠病学 儿科胃肠病学
背景情况:
- 肠道微生物群和代谢组影响便的一致性,但早期儿童的关系尚不清楚.
- 便的一致性受过渡时间,饮食,液体摄入量和整体肠道健康状况的影响.
研究的目的:
- 调查肠道微生物群,代谢组和婴儿和幼儿的便一致性之间的联系.
- 探索母乳养对婴儿肠道微生物组成和代谢物概况的影响.
主要方法:
- 分析了来自2.5至30个月的儿童的618个便样本.
- 微生物群和代谢组数据与便水含量和父报告一致性的相关性.
- 利用了来自FinnBrain出生队列研究的数据.
主要成果:
- 哺乳期与便一致性和便含水量有着最强烈的关联.
- 微生物胆酸胺基与便秘和便水分减少有关,而SCFA显示混合关联.
- 特定的细菌系 (例如,Clostridium,Lactobacillus) 与更坚固的便有关.
结论:
- 便一致性文件在便代谢学和微生物组研究中至关重要.
- 研究结果提供了关于母乳养,微生物代谢和肠道传输时间如何影响早期肠道发育的见解.
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