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高度原发性前列腺瘤中的空间组织的淋巴细胞微环境

Ali Amiryousefi^1,2, Jeremiah Wala³, Jia-Ren Lin^1,2

¹Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

bioRxiv : the preprint server for biology

|September 26, 2025

概括

高度前列腺癌 (PCa) 显示B和T细胞透的增加,形成有组织的免疫,类似于三级淋巴细胞结构 (TLS). 这些结构可能有助于瘤控制,并在晚期PCa中提供治疗点.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

瘤免疫微环境 (TME) 影响癌症的进展.
在原发性前列腺癌 (PCa) 中的TME组织尚未得到充分理解.

研究的目的:

为了研究免疫细胞的空间组织和组成在高等级与低等级的PCa.
在初级前列腺癌中表征TME.

主要方法:

在29个急性前列腺切除标本中,对免疫细胞丰度和空间分布的概述.
标本分层成高格莱森度 (HGG) 和低格莱森度 (LGG) PCa.

主要成果:

与LGG PCa相比,HGG PCa的B细胞和T细胞透率显著更高.
在HGG瘤中的免疫细胞形成有组织的,其中一些类似于三级淋巴体结构 (TLS).
这些HGG群是密集的,富含PD-1+T细胞,位于瘤附近,与较少组织的LGG群不同.

结论:

高度PCa的一个子集具有有组织的免疫集群,可能参与瘤控制.
这些免疫群包含可治疗的T细胞和B细胞,这表明新型PCa治疗的潜力.

关键词:

前列腺癌是什么意思前列腺癌是什么意思免疫透免疫透是什么?多重成像成像多重成像空间生物学空间生物学瘤微环境是一个微环境.

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