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Updated: Jul 6, 2026

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
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调节谷氨胺新陈代谢重新编程了巨细胞的亲炎症分化

Sumeng Qi1,2, Jiawei Fan1,2, Dao-Sian Wu2

  • 1Graduate Program in Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University.

bioRxiv : the preprint server for biology
|September 26, 2025
PubMed
概括

谷氨胺类同类药物DON最初抑制,然后增强M1巨细胞的活性,维持促炎反应. 它还抑制免疫抑制M2和瘤相关巨细胞 (TAMs) 在癌症中.

关键词:
这就是为什么BMDM BMDM谷氨胺的新陈代谢巨细胞的分化有助于炎症的基因瘤微环境 瘤微环境

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Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...