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Updated: Jan 16, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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在黑色素瘤中,YAP1通过重编程染色质和调节免疫逃避程序来驱动攻击性和耐治疗状态

Nana Chen, Gracia Bonilla, Abdullah Ai Emran

    bioRxiv : the preprint server for biology
    |September 26, 2025
    PubMed
    概括

    通过改变色素,YAP1激活驱动黑色素瘤的治疗耐药性. 用特定的抑制剂向TEAD可以克服这种耐药性并增强抗瘤免疫力,为患者提供新的希望.

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