QSProteome:一个社区驱动的互动平台,用于大规模探索和评估预测的蛋白质复杂结构
bioRxiv : the preprint server for biology
|September 26, 2025
概括
QSProteome是一个用于建模和精制蛋白质结构的新平台. 这种由社区驱动的资源使得蛋白质组规模的结构生物学数据可访问,并促进蛋白质复合体的协作改进.
科学领域:
- 结构生物学是结构生物学.
- 计算生物学是一种计算生物学.
- 生物信息学是一种生物信息学.
背景情况:
- 四次性蛋白质结构建模和评估对于理解生物功能至关重要.
- 现有的资源往往缺乏全面的,社区驱动的细化能力,用于大规模的蛋白质复杂数据.
研究的目的:
- 介绍QSProteome,这是一个社区规模的平台,用于建模,评估和改进四级蛋白质结构.
- 为蛋白质细胞尺度结构生物学研究提供一个动态,可扩展的基础设施.
- 为了使社区主导的评估和蛋白质复杂结构的代改进.
主要方法:
- 托管来自BioCyc和ComplexPortal数据库的35528个独特的模型蛋白质组合.
- 使用交互式3D可视化,信心指标,结构对齐和每个模型的功能注释.
- 实现基于云的服务器,用于连续的用户上传和自动处理,包括游戏化的重复处理工作流.
主要成果:
- 目前QSProteome拥有超过35,528个建模的蛋白质组合,覆盖了广泛的策划复杂的数据库.
- 该平台在14周内成功处理和验证了超过54,000个模型.
- 一个由社区主导的评估1547个ABC传送器综合体通过re-curation工作流程得到了便利.
结论:
- QSProteome为蛋白质组规模结构生物学提供了一个统一的,可搜索和可扩展的框架.
- 该平台提高了结构数据的可访问性和可重复使用性,促进了发现和注释.
- 通过游戏化工作流程,社区参与推动了代的改进,并推进了协作结构生物学研究.
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