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Updated: Jan 16, 2026

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
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使用CRI-SPA-Map进行高分辨率,无基因型的基因变异映射

Sheila Lutz1, Megan Lawler1, Samuel Amidon1

  • 1Department of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN 55455, USA.

bioRxiv : the preprint server for biology
|September 26, 2025
PubMed
概括

我们开发了CRI-SPA-Map,这是一种使用CRISPR-Cas9和酵母中的选择性性切除 (SPA) 的经济有效的基因绘图策略. 这种方法精确地识别出影响酵母生长和基因与环境相互作用的基因变异,如MKT1和SAL1中的基因变异.

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