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Updated: Jan 16, 2026

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
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通过基因组学信息的基因组语言模型预测跨进化时间尺度的功能约束

Chengzhong Ye1, Gonzalo Benegas2, Carlos Albors2

  • 1Department of Statistics, University of California, Berkeley, Berkeley, CA, USA.

bioRxiv : the preprint server for biology
|September 26, 2025
PubMed
概括

基因组语言模型 (gLMs) 得到了GPN-Star的增强,这是一个使用物种树和对齐的新的生物接地模型. 这种方法改善了变异效应预测,并为人类遗传学研究优先考虑致病变异.

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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