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Updated: Jun 19, 2026

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PTPN2-KO CAR-T 细胞在非人类灵长类 CAR-T 模型中表现出增强的效应器功能,中枢神经系统透和毒性

Francesca Alvarez Calderon, Ryan A Fleming, Marlana Winschel

    bioRxiv : the preprint server for biology
    |September 26, 2025
    PubMed
    概括

    在仿真抗原受体T (CAR-T) 细胞中删除PTPN2可以增强它们对抗癌症的能力. 然而,在临床前模型中,这种修改也增加了严重毒性的风险,特别是神经毒性.

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    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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