肺部保护的FLASH-RT:对机制,技术进步和临床翻译的全面审查
Yixue Wen1, Xinlan Liu2,3, Xiaohong Zhang1
1Breast Disease Center, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Frontiers in oncology
|September 26, 2025
概括
超高剂量率FLASH辐射疗法在癌症治疗中节省肺组织的前景很有希望. 本综述探讨了FLASH-RT的机制和技术.
科学领域:
- 辐射瘤学 辐射瘤学
- 肺部医学 肺部医学
- 癌症生物学 癌症生物学
背景情况:
- 闪光辐射疗法 (FLASH-RT) 使用超高剂量率 (>40 Gy/s) 来实现显著的正常组织节约,同时保持瘤控制.
- 肺部保护是胸部瘤学的主要挑战,需要创新的治疗策略.
研究的目的:
- 批判性地评估FLASH-RT肺部保护作用背后的机制.
- 在体外,体内和临床研究中评估拟议机制的证据质量.
- 总结一下促进FLASH-RT用于肺部保护的临床翻译的技术进步.
主要方法:
- 关于FLASH-RT和肺部保护的临床前和临床研究的全面审查.
- 对拟议的生物和物理机制 (例如,氧气耗尽,基因重组,DNA完整性) 的批判性评估.
- 分析技术创新,包括光束模式,剂量测量和运动管理.
主要成果:
- 在胸部瘤学中,FLASH-RT显示出正常肺组织的潜力.
- 提出了多种机制,包括代谢调节和免疫重编程,但需要进一步验证.
- 技术进步正在为FLASH-RT的临床实施铺平道路.
结论:
- FLASH-RT为缓解辐射诱导的肺毒性提供了一个有希望的方法.
- 需要进一步的研究来阐明明确定的机制和优化临床方案.
- 本综述提供了一个统一的模型,以指导未来的FLASH-RT肺部保护的研究和临床试验.
相关概念视频
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
328
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
328
Pulmonary Hypertension: Classification and Pathogenesis
576
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
576
Pulmonary Embolism I: Introduction
516
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
516
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
475
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
475
Transmission-based Precautions II: Airborne and Protective Environment
1.8K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.8K


