饮食维生素B2和E与认知表现的剂量依赖相互作用:老年人的横截面研究
Yueju Wu1, Hai Zhou2, Yong Cai1
1Department of Neurology, Binhai County People's Hospital, Binhai Clinical College, Yangzhou University Medical College, Yancheng, China.
Frontiers in nutrition
|September 26, 2025
概括
饮食中摄入维生素B2和维生素E独立地有利于老年人的认知功能. 它们的综合摄入显示出复杂的相互作用,在较低的维生素E水平下产生协同效应,影响认知表现.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 认知神经科学 认知神经科学
背景情况:
- 个人维生素饮食与认知功能的关联得到了充分研究.
- 维生素B2和维生素E对认知的联合影响尚不清楚.
研究的目的:
- 研究饮食维生素B2和维生素E对老年人认知表现的相互作用作用.
- 分析组合营养摄入量如何影响老年人群的认知功能.
主要方法:
- 从NHANES 2011-2014对2,497名老年人 (≥60岁) 的横截面分析.
- 通过数字符号替换测试 (DSST) 评估认知功能;低性能定义为最低四分位数.
- 多变量逻辑回归模型分析了维生素B2和维生素E摄入的独立和联合关联,并量化了相互作用效应.
主要成果:
- 增加的维生素B2和维生素E摄入量独立地与较低的认知功能差的几率有关.
- 观察到维生素B2和维生素E之间存在显著的多重相互作用 (OR=1.15,p<0.05).
- 在维生素E摄入量<18毫克/天时出现了协同效益,而超出这一门时出现了对抗作用. 双高摄入量显示出最强的保护作用 (OR=0.44).
结论:
- 在调节认知表现方面,维生素B2和维生素E之间存在剂量依赖的相互作用.
- 饮食指南应考虑老年人群的营养相互作用模式.
- 优化维生素B2和维生素E的综合摄入可能有助于老年人的认知健康.
相关概念视频
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
188
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
188
01:15Drug Dosing: Geriatric Patients
227
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
227
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
197
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
197
01:30Vitamins
2.3K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
228
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
228
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
232
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
232