皮肤微生物组与白素-23在患有斑块性牛皮的患者中的关联
Hanan Hassan Sabry1, Zainab Sami Noor1, Rasha Abdel Hameed Elsayed2
1Dermatology, Venereology and Andrology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Postepy dermatologii i alergologii
|September 26, 2025
概括
牛皮患者的真菌生长增加,与健康人群相比,Interleukin-23 (IL-23) 水平降低. 这些因素,以及微生物组的变化,可以作为皮病诊断和管理的生物标志物.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 牛皮是一种慢性自身免疫性疾病,与免疫失调和皮肤微生物组变化有关.
- 干白素-23 (IL-23) /T助手17 (Th17) 途径在牛皮病原发生过程中至关重要.
- 皮肤微生物组失调和牛皮中的IL-23水平之间的相互作用需要进一步研究.
研究的目的:
- 分析斑块性牛皮患者的皮肤微生物组变异,与健康对照对比.
- 评估血清IL-23水平,IL-23遗传多态和牛皮之间的相关性.
- 探索这些因素与牛皮严重程度之间的关系.
主要方法:
- 一项涉及40名牛皮患者和40名健康对照者的病例控制研究.
- 通过培养方法进行皮肤微生物组分析.
- 使用ELISA测量血清IL-23水平,并通过PCR-RFLP对IL-23rs2201841多态的基因定型.
主要成果:
- 牛皮患者的真菌生长显著增加 (75%对17.5%) 和混合细菌和真菌感染 (55%对15%).
- 血清IL-23水平在患者中较低 (157.2 pg/ml与252.7 pg/ml),并且与牛皮区域和严重性指数 (PASI) 分数负相关 (r = -0.866).
- 生长 (OR=3.61) 和降低IL-23水平 (OR=0.996) 独立预测了牛皮的易感性,而rs2201841 SNP没有显著的关联.
结论:
- 皮肤微生物组的改变,特别是真菌存在的增加,与牛皮有关.
- 较低的血清IL-23水平与牛皮的严重程度相关.
- 真菌感染和IL-23水平显示出潜力作为牛皮的生物标志物用于牛皮的诊断和监测.
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