在重病儿童中使用非标签的高剂量万科米辛的药物监督实践
Min Qin1, Wenwen Chen1, Bin Lu2
1Department of Pharmacy, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
危急病患儿童高剂量范科米辛可能会导致损伤. 实施加强监测和个性化剂量策略显著减少了儿科重症监护病房的不良事件.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 非标签的高剂量万科米辛用于重病儿童.
- 由于潜在的毒性,万科米辛的剂量需要仔细考虑.
- 儿科重症监护室 (PICU) 面临着管理高剂量抗生素治疗方案的挑战.
研究的目的:
- 评估非标签高剂量万科米辛在重症儿童的安全性.
- 确定与高剂量万科米辛治疗相关的降低风险的策略.
- 评估改善监测对与木相关的不良事件的影响.
主要方法:
- 一项回顾性病例对照研究分析了39名PICU患者的万科米辛治疗.
- 调查了一起与非标签高剂量万科米辛 (> 40 mg/kg/day) 相关的急性损伤病例.
- 实施干预措施,包括加强最低度监测和个性化剂量.
主要成果:
- 51.3%的患者接受了非标签的高剂量万科米辛.
- 25%的高剂量万科米辛患者出现了不良反应,包括严重的病例.
- 干预实施后,在86名接受治疗的儿童中没有观察到与万科米辛相关的急性损伤病例.
结论:
- 在重病的儿童中,高剂量的万科米辛会导致功能障碍的风险.
- 加强治疗药物监测和个性化治疗方案对于安全使用万科米辛至关重要.
- 积极的临床药物安全实践对于预防万科米辛诱导的毒性至关重要.
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