一个儿科病人的第一个报告Pascalia glauca中毒病例:一个病例报告
Andrea Milena Rodríguez-Guerrero1, Tania Galán2, Marjorie Rodríguez-Guerrero2
1Ministry of Public Health, Atacames Health Center, Esmeraldas, Ecuador.
Frontiers in medicine
|September 26, 2025
概括
本案例报告详细介绍了南美植物帕斯卡利亚格劳卡 (Pascalia glauca) 首次对人类的中毒. 摄入导致儿童严重的神经毒性和肝毒性影响,包括和肝功能衰竭.
科学领域:
- 毒理学 毒理学 毒理学
- 临床案例研究 临床案例研究
- 神经科学是一个神经科学.
背景情况:
- 帕斯卡利亚·格劳卡 (Pascalia glauca) 是一种南美植物,已知对动物造成严重的肝脏和脏毒性.
- 它的毒性源于carboxyatractyloside,它破坏了线粒体腺三酸盐 (ATP) 运输.
- 之前没有记录过人类中毒病例.
研究的目的:
- 报告第一个被Pascalia glauca.人类中毒的病例.
- 描述这种中毒的临床表现,管理和结果.
- 突出帕斯卡利亚格劳卡在人类中的神经毒性和肝毒性潜力.
主要方法:
- 一个案例报告,一个6岁的男孩在摄入了Pascalia glauca之后.
- 临床评估,部CT扫描和实验室调查.
- 用抗药,神经保护药和肝衰竭的支持性护理进行治疗.
主要成果:
- 患者经历了强力克隆性发作,意识变化和吐.
- 部CT检测显示了皮出血;实验室检测显示了转氨酶和凝血病的升高,进展到急性肝衰竭.
- 尽管接受了治疗,但在儿科重症监护室27天后,该患者仍存在持续的神经损伤.
结论:
- 这是第一个报告的人类病例Pascalia glauca中毒,显示显著的神经毒性和肝毒性作用.
- 这一案例强调了需要提高医疗保健专业人员的认识,并进一步开展毒理学研究.
- 由于缺乏先前的人类数据,存在管理和预后方面的挑战.
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