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循环中甲素K作为老年人肉类的生物标志物:一个病例对照研究

Huaqing Liu¹, Hongdou Liu², Yan Xing¹

¹Department of Gastroenterology, Nanyang Central Hospital, Nanyang, Henan, China.

Frontiers in medicine

|September 26, 2025

背景:

本研究探讨了老年个体中循环组织蛋白酶K（CatK）和组织蛋白酶D（CatD）水平与肌肉减少症之间的关系。

方法:

本病例对照研究纳入了来自南阳中心医院的343名年龄超过65岁的参与者。根据亚洲肌少症工作组（AWGS）标准诊断肌少症，诊断需满足手握力（HGS）降低和四肢骨骼肌质量（ASM）减少两项指标。采集空腹血液样本，通过ELISA法检测CatD和CatK水平。研究比较了各组间CatD和CatK水平的差异，并采用ROC曲线分析评估其诊断价值。

结果:

血清 CatK 水平在握力低、骨骼肌质量低及患有肌少症的受试者中显著升高（均p< 0.05）。CatK 与 HGS 呈负相关（β = -0.899，p= 0.016），对肌少症具有诊断价值，其AUROC为0.704。CatD水平未显示显著差异或相关性。肌少症的最佳CatK截断值为5.53 ng/mL，较高的CatK与低握力（HGS）风险增加相关（OR = 1.895，p= 0.014）和肌少症（OR = 3.926，p< 0.001。

结论:

循环CatK是肌少症的一种有前景的生物标志物，有望用于早期诊断和治疗靶向。

关键词:

卡瑟普辛 D D D D D 卡瑟普辛 D 凯瑟普辛K 凯瑟普辛K 凯瑟普辛年龄较大的成年人.这种类型的麻症是sarcopenia.这是骨肌肉的骨架肌肉.

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