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Updated: Jan 16, 2026

Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
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在临床前阿尔茨海默病中的核心1生物标志物的连续性

Leonardino A Digma1, Christina B Young1, Joseph R Winer1

  • 1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

medRxiv : the preprint server for health sciences
|September 26, 2025
PubMed
概括

早期阿尔茨海默病 (AD) 的生物标志物,血p-tau217和粉样蛋白-PET,预测了临床无损的个体未来的疾病进展. 在A阶段,这些核心生物标志物表明下游变化和认知衰退的风险增加.

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