在拉丁裔中,确定痴呆症8 (AD8) 问卷的最佳切线,认知障碍诊断性能,可靠性和并发有效性
Jaime Perales-Puchalt1, Adam Parks1, Tina Lewandowski1
1Alzheimer's Disease Research Center; Department of Neurology; University of Kansas Medical Center; Fairway, KS, USA.
medRxiv : the preprint server for health sciences
|September 26, 2025
概括
确定痴呆症8 (AD8) 问卷有效地选美国拉丁裔的认知障碍. 这项研究验证了AD8的有效性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 心理测量 心理测量 心理测量
背景情况:
- 认知障碍查对于早期发现痴呆症至关重要.
- 确定痴呆症8 (AD8) 是一个简短的认知障碍问卷.
- 在像美国拉丁裔这样的不同人群中验证查工具是必不可少的.
研究的目的:
- 在英语和西班牙语的美国拉丁裔中验证AD8问卷的诊断性能和心理测量特性.
- 为了确定这个人群中AD8的最佳切断分数.
- 为了比较AD8.8的英语和西班牙语版本的性能.
主要方法:
- 对46名美国拉丁裔参与者的交叉剖析数据进行了交叉剖析.
- 接收器操作特征 (ROC) 分析以评估诊断性能.
- 库德-理查德森公式20用于内部一致性和与已建立的认知验证有效性测试的相关性.
主要成果:
- 在AD8中,确定了3或更高的最佳切断分数.
- 该AD8的敏感度为73.7%,特异性为85.2% (AUC=0.843).
- 观察到良好的内部一致性 (0.872) 和与其他认知指标的预期相关性;西班牙语版本表现更好.
结论:
- AD8问卷具有足够的心理测量特性和诊断性能,用于选美国拉丁裔的认知障碍.
- 这是AD8在美国拉丁裔中首次得到验证,支持其临床和研究用途.
- 研究结果表明,AD8对于服务拉丁裔人口的医疗机构来说是一个有价值的工具.
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