美国老年人中DNA甲基化年龄偏差和认知状态,NHANES 1999-2002
Erika Walker1, Scarlet Cockell1, Belinda L Needham1
1Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
medRxiv : the preprint server for health sciences
|September 26, 2025
概括
通过DNA甲基化测量生物衰老,可以预测老年人的认知功能. 加速衰老标记与认知测试得分较低有关,这表明DNA甲基化.
科学领域:
- 表观遗传学和衰老的研究
- 神经科学是一个神经科学.
- 生物标志物发现发现
背景情况:
- 通过DNA甲基化评估的生物衰老是认知健康的新兴生物标志物.
- 了解衰老生物标志物与认知衰退之间的联系对于公共卫生至关重要.
研究的目的:
- 研究多种基于DNA甲基化的生物衰老和老年人的认知表现之间的关联.
- 探索性别,教育和种族/民族的潜在效果修改.
主要方法:
- 利用来自国家健康和营养检查调查 (NHANES) (1999-2002) 的全基因组DNA甲基化数据.
- 计算出13种不同的生物衰老指标.
- 使用数字符号替换测试 (DSST) 评估认知功能.
- 雇员调查加权线性回归模型,对相关共变量进行调整.
主要成果:
- 在13项DNA甲基化测量中,10项显示与DSST得分有显著关联 (调整后p<0.05).
- GrimAge2加速衰老的每一年都与DSST得分下降0.41个点有关 (p=5×10-4).
- 在男性和非西班牙裔白人参与者中观察到更强的关联.
结论:
- 生物衰老的DNA甲基化指标与60岁及以上的成年人的认知状态有关.
- 这些发现表明,DNA甲基化可以作为一种有价值的生物标志物,用于老年人群的认知健康.
- 效果修改表明老龄化生物标志物对人口群体认知的不同影响.
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