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休活动的频率或多样性对表观遗传衰老更重要吗? 对艺术参与和体育活动的分析
Daisy Fancourt1, Lehané Masebo2, Saoirse Finn1
1Department of Behavioural Science and Health, University College London.
medRxiv : the preprint server for health sciences
|September 26, 2025
概括
参与艺术,文化和体育活动与缓慢的生物衰老有关,特别是在中年和老年人中. 这些活动的频率和多样性影响了像PhenoAge和DunedinPACE这样的老化时钟.
科学领域:
- 老年学是指老年学的学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生活方式 医学 医疗
背景情况:
- 老化时钟越来越多地用于评估生物年龄.
- 休活动,如艺术/文化参与 (ACEng) 和体育活动 (PA) 对表观遗传衰老的影响还没有得到充分研究.
- 了解参与频率与多样性的作用至关重要.
研究的目的:
- 为了研究ACEng,PA和表观遗传衰老之间的关系.
- 为了确定是否参与频率或多样性对生物衰老更有影响.
- 在不同的表观遗传钟和年龄组中分析这些影响.
主要方法:
- 利用了来自英国家庭长度研究中的3,354名英国成年人的数据.
- 雇佣的两倍强大的估计,调整了许多共同变量.
- 分析了七个衍生的表观遗传时钟,包括PhenoAge,DunedinPoAm和DunedinPACE.
主要成果:
- 无论是ACEng还是PA都与PhenoAge,DunedinPoAm和DunedinPACE时钟的老化速度减缓有关.
- 对于ACEng,多样性和频率对DunedinPoAm和DunedinPACE产生了影响;频率与PhenoAge的关系略大.
- 与DunedinPoAm和DunedinPACE相关的PA频率,多样性和活力;与PhenoAge相关的更高水平. 影响在中年和老年人中更为强烈.
结论:
- 艺术,文化参与和体育活动显示出减缓表观遗传衰老的潜力.
- 参与的频率和多样性都显得很重要,在不同的衰老时钟中都有细微差别.
- 这些发现支持进一步研究减轻生物衰老的生活方式干预措施.
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