一个暴露体范围的相互作用研究,以识别影响敏感人群的隐藏环境因素:适用于化学-社会脆弱性对认知功能的相互作用
Sung Kyun Park1,2, Erika Walker1, Laura Arboleda-Merino1
1Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
medRxiv : the preprint server for health sciences
|September 26, 2025
概括
这项研究表明,某些环境化学物质会影响认知功能,特别是在社会弱势群体中. 一项全暴露组相互作用研究确定了传统方法遗漏的化学物质,强调了在环境风险评估中需要考虑社会脆弱性的必要性.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 暴露组范围的关联研究 (ExWAS) 通常评估环境暴露对健康的平均影响.
- 这种方法可能无法识别影响特定敏感亚群的化学品.
- 社会脆弱性是可以改变环境化学影响的关键因素.
研究的目的:
- 进行全暴露体相互作用研究 (ExWIS),以确定与认知功能相关的环境化学物质.
- 调查社会脆弱性在改变这些关联中的作用.
- 突出影响敏感人群的化学物质,可能会被标准ExWAS遗漏.
主要方法:
- 研究了147种基于生物标志物的化学物质与4982名老年人的认知功能之间的关联 (NHANES 1999-2014).
- 根据人口统计,社会经济地位和健康指标计算社会脆弱性指数 (SVI).
- 采用线性回归模型来评估化学物质和SVI之间对认知功能的边际关联和相互作用效应.
主要成果:
- 边际关联模型确定了16种与认知功能相关的化学物质 (例如,吸烟相关的化合物,PAH,金属).
- 相互作用模型揭示了另外四种化学物质 (尿液中的,二甲基酸盐, perfluorononanoate, perfluoroundecanoate) 与SVI有显著的相互作用.
- 在边际关联模型中没有检测到这四种化学物质,这强调了相互作用分析的重要性.
结论:
- ExWIS框架有效地识别了影响敏感人群的环境因素.
- 考虑与社会脆弱性的相互作用效应对于准确的环境风险评估至关重要.
- 这种方法对于在风险人群中识别神经毒素至关重要.
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