确定护理人员报告的儿童瘤学临床试验招生和参与的可修改障碍
Rebecca Whitmire1, Daniel Wikstrom2, Robin Lockridge2
1Johns Hopkins Sydney Kimmel Comprehensive Cancer Center.
Research square
|September 26, 2025
概括
社会经济地位,家庭物质困难和低健康素养造成了儿童癌症临床试验参与的障碍. 解决这些可修改的因素可以改善儿童癌症护理的获取和减少差异.
科学领域:
- 儿科瘤学 儿科瘤学
- 健康差异 在健康上的差异
- 临床试验招生情况
背景情况:
- 临床试验 (ClTr) 的参与对于推进儿科瘤治疗至关重要.
- 显著的社会人口差异阻碍了公平获得ICT的机会.
- 识别可修改的障碍,如家庭物质困难 (HMH) 和健康素养 (HL),对于改善 ClTr 招生至关重要.
研究的目的:
- 通过社会经济地位 (SES) 和种族/种族群体,比较护理人员报告的儿科瘤临床治疗参与障碍.
- 探索护理人员HL,HMH和CLR参与障碍之间的关联.
主要方法:
- 一项全国性的匿名在线调查对在过去5年内被诊断患有癌症的儿童的照顾者进行了管理.
- 护理人员完成了研究参与调查 - 护理人员 (RPS-C),健康素养调查-12 (HLS-19-Q12),以及HMH的WellRx问卷.
- 参与者包括英语和/或西班牙语的护理人员.
主要成果:
- 64%的参与者在社会经济上缺乏资源,52.5%属于代表不足的种族/民族群体.
- 与资源充足的照顾者相比,缺乏资源的照顾者报告说,与有足够资源的照顾者相比,临床治疗参与的障碍明显更高 (p=0.001).
- 较低的HL (ρ=0.557,p<0.001) 和较高的HMH (ρ=0.562,p=0.006) 与障碍的增加有关,90%以上的受访者表示难以理解研究风险.
结论:
- 在社会经济上缺乏资源的护理人员面临着更大的障碍,无法参与儿科癌症临床治疗.
- 家庭的物质困难和较低的健康素养是与这些障碍相关的重要因素.
- 针对这些可修改障碍的干预措施可以增强 ClTr 获取,并减少儿童癌症结局的差异.
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