用抗生素重塑肠道微生物组可以减少创伤性脑损伤中的神经炎症
Hannah Flinn1, Austin Marshall1,2, Morgan Holcomb1
1Department of Neurosurgery and Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA.
Research square
|September 26, 2025
概括
抗生素可以通过改变肠道微生物组来减少创伤性脑损伤 (TBI) 后的脑炎症和损伤. 这表明潜在的微生物向疗法用于TBI恢复.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 创伤性脑损伤 (TBI) 与神经炎症和肠道微生物组破坏有关.
- 抗生素 (ABX) 对TBI相关神经病理学的影响尚不清楚.
研究的目的:
- 研究抗生素诱导的肠道微生物群枯竭对小鼠TBI结局的影响.
- 探索肠道微生物在TBI诱导的神经炎症和神经退行症中的作用.
主要方法:
- 在单次和重复的TBI模型中给雄性小鼠服用广泛的口服抗生素.
- 评估神经炎症,神经退行,肠道微生物组合和短链脂肪酸水平.
- 使用无细菌小鼠和元基因组分析.
主要成果:
- 在TBI后的雄性小鼠中,抗生素治疗显著降低了神经炎症和神经退行.
- 创伤加剧了肠道损伤和失生症,而抗生素改变了微生物组合,减少了短链脂肪酸.
- 没有细菌的小鼠在TBI后增加了神经炎症和病变体积,突出显示了微生物组的保护作用.
结论:
- 短期使用抗生素可以通过调节肠道微生物群来减轻TBI诱导的神经炎症.
- 特定的细菌种群如 *Parasutterella excrementihominis* 和 *Lactobacillus johnsonii* 可能会在受伤后抵抗抗生素的影响.
- 研究结果表明,对TBI的微生物向治疗策略有潜力.
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