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结构神经成像痴呆症标记:ROC曲线分析的见解

Sam Pepper¹, Setorwu Dzesu¹, Lauren Yoksh¹

¹University of Kansas Medical Center.

Research square

|September 26, 2025

概括

阿尔茨海默病和相关痴呆症 (ADRD) 可以更早地使用MRI生物标志物进行诊断. 阿尔茨海默氏症的特征和海马占用率 (HOC) 显示为区分认知障碍阶段最有前途.

科学领域:

神经成像是一种神经成像.
生物标志物生物标志物
认知神经科学认知神经科学

背景情况:

阿尔茨海默病和相关痴呆症 (ADRD) 是一个重大的公共卫生挑战.
认知衰退的早期和准确的诊断,从认知正常 (NL) 到轻度认知障碍 (MCI) 和痴呆症,对于及时干预至关重要.
结构磁共振成像 (MRI) 生物标志物,包括灰质体积 (GMV),白质体积 (WMV),白质超强度体积 (WMH),AD签名和海马体占用率 (HOC),显示出客观地分阶段认知衰退的潜力.

研究的目的:

评估MRI衍生的神经成像测量的诊断实用性.
通过接收器操作特征 (ROC) 曲线分析,确定区分NL,MCI和痴呆症的最佳门.

主要方法:

来自KU阿尔茨海默氏病研究中心的466名参与者的数据 (2010-2025年).
使用SPM12和VBM12进行预处理的T1加权MRI扫描.
统计分析包括ANOVA,Tukey的HSD,Welch的t测试和ROC分析与优选切割点的Youden的J统计.

主要成果:

在诊断组之间观察到GMV,WMH,AD签名和HOC的显著差异.
对于单个生物标志物的ROC分析显示了高AUC:HOC (0.878) 和AD签名 (0.829) 对于Demented和NL.
在区分MCI/痴呆症与NL (AUCs = 0.78,0.81) 和MCI与痴呆症 (AUCs = 0.70,0.73) 方面,AD特征和HOC表现出强的表现.

结论:

来自MRI的生物标志物,特别是AD签名和HOC,显示出区分认知障碍阶段的巨大潜力.
基于ROC的值提供了临床可行的指标,以提高ADRD的诊断精度.

关键词:

生物标志物生物标志物痴呆症是一种痴呆症.神经成像是一种神经成像.在ROC曲线上,ROC曲线结构性核磁共振成像 (MRI)

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