一家人在战争中-反对Tropheryma whipplei:一个案例系列
Daina Lasaitiene1,2, Marie Kebke1, Anna Grankvist3
1Department of Rheumatology, Södra Älvsborg Hospital, Borås, Sweden.
Open forum infectious diseases
|September 26, 2025
概括
惠普尔病 (WD) 可以影响多个器官系统,包括心脏和眼睛. 这一案例凸显了在患有不明原因的全身炎症和心脏干扰的患者中考虑WD的重要性.
科学领域:
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
- 眼科医生 眼科 眼科
背景情况:
- 惠普尔病 (WD) 是一种罕见的系统性传染病,由Tropheryma whipplei.引起.
- 胃肠病通常影响胃肠道,但可以表现在各种器官,包括心脏,关节和中枢神经系统.
- 诊断可能是具有挑战性的,因为它的稀有性和不同的临床表现.
研究的目的:
- 报告怀普尔病的病例,表现为内心炎和胆膜炎.
- 为了调查威普尔病的潜在家族发生情况.
- 强调PCR和PAS染色在Tropheryma whipplei感染中的诊断实用性.
主要方法:
- 临床病例介绍和诊断工作.
- 聚合酶连锁反应 (PCR) 测试在血液和十二指肠活检.
- 十二指肠活检的定期酸-Schiff (PAS) 染色.
- 胸外心电回声学. 胸外心电回声学.
主要成果:
- 一名29岁的妇女被诊断出患有惠普尔病,该诊断是基于十二指肠活检的阳性PCR和PAS染色,以及内心炎和胆膜炎.
- 血液培养最初是负面的,强调了扩大诊断的需要.
- 怀疑家族性WD的原因是近亲患有类似症状,两名亲属确诊病例.
结论:
- 惠普尔病可以表现为心脏和眼睛的表现,需要高度的怀疑指数.
- PCR和PAS染色对于诊断Tropheryma whipplei感染至关重要,特别是当血液培养结果为阴性时.
- 惠普尔病的家族传播或遗传倾向的可能性需要进一步调查.
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