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长期暴露于超细颗粒和心血管疾病:中国的一项大型多中心研究

Tingting Yang¹, Yixiang Zhu², Renhua Zhang¹

¹School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 561113, China.

Environmental science & technology

|September 26, 2025

概括

长期暴露于超细颗粒物 (UFP) 显著增加了心血管疾病 (CVD) 的患病率,包括中风,冠心病和高血压,没有确定安全门.

科学领域:

环境健康环境健康
心血管流行病学心血管流行病学
空气污染研究研究

背景情况:

超细颗粒物 (UFP) 构成严重的环境健康风险.
暴露于UFP的长期心血管影响尚不清楚.
中国面临着高水平的UFP暴露,需要研究其对健康的影响.

研究的目的:

调查长期UFP暴露与中国心血管疾病 (CVD) 患病率之间的联系.
量化与UFP暴露相关的特定CVD风险的增加.
确定受UFP相关心血管疾病不成比例地影响的弱势群体.

主要方法:

利用了来自中国五个省/地区的98,797名参与者的数据.
采用高分辨率的大气化学模型来估计3年的UFP平均暴露.
进行了一项大规模的多中心流行病学研究,以分析关联.

主要成果:

总体心血管疾病,中风,冠心病和高血压的患病率增加,与长期暴露于UFP有关.
总体心血管疾病的几率比为每四分位数间范围增加1.17的UFP (5667颗粒子/厘米3).
没有观察到值效应;即使在较低的UFP水平上,风险也会线性增加,对老年人,少数民族和城市居民的影响更大.

结论:

长期暴露于UFP是中国总体和特定心脏病发病率增加的重要风险因素.
调查结果凸显了对UFP缓解策略的迫切需要,特别是在发展中国家.
这项研究提供了关于UFP在高暴露环境中的心血管影响的关键流行病学证据.

关键词:

空气污染空气污染心血管疾病心血管疾病冠心病是一种冠心病.跨截面研究是跨截面研究.这种高血压是高血压.一次性中风中风中风中风中风超细颗粒物是一种超细颗粒物.

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