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空间意识调整的Rand指数用于评估空间转录学集群.
Yinqiao Yan1, Xiangnan Feng2, Xiangyu Luo3
1School of Mathematics, Statistics and Mechanics, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, China.
Biometrics
|September 26, 2025
概括
我们介绍了空间意识的兰德指数 (spRI) 和spARI,以更好地评估空间转录组学集群. 这些指标包括空间距离,比ARI等传统方法提高了准确性.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 空间转录学 (ST) 聚类对于理解组织异质性至关重要.
- 精确的ST聚类可以提高下游的生物分析.
- 目前的基准测试方法缺乏空间意识.
研究的目的:
- 提出新的指标,spRI和spARI,用于评估ST集群.
- 为了解决空间数据中调整后的兰德指数 (ARI) 的局限性.
主要方法:
- 开发了具有空间意识的兰德指数 (spRI),结合了对象距离.
- 引入了空间意识调整的兰德指数 (spARI),对随机机会进行了调整.
- 使用模拟研究和真实ST数据集评估指标.
主要成果:
- spRI和spARI有效地结合了空间距离信息.
- 拟议的指标有利于聚类中的空间连贯性.
- 在评估ST集群方法方面,spARI显示了比ARI更好的实用性.
结论:
- spRI和spARI提供了更准确的空间ST集群评估.
- 这些指标提供了比ARI更好的空间连贯性评估.
- 拟议的方法提高了ST集群方法的基准测试.
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