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在体中研究基于三氨酸的新型拓酶抑制剂

Mukesh Kumar Kumawat1, Kapil Kumar2

  • 1School of Pharmaceutical Sciences, Apeejay Stya University, Gurugram, Haryana, 122103, India.

Medicinal chemistry (Shariqah (United Arab Emirates))
|September 26, 2025
PubMed
概括

研究人员为癌症药物发现设计了新的三氨酸模拟混合体. 与现有药物相比,六种强效化合物显示出优异的DNA拓酶抑制,为新的抗癌疗法铺平了道路.

关键词:
在ATPase领域中,三甲林是一种三甲林.这是一种抗瘤.滑翔非常精确的对接.摩尔灵感灵感是一种灵感.药物动力学 药物动力学毒性酶二甲基酶IIα 的存在.

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DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
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