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药物输送系统用于克服癌症治疗中的物理障碍

Xiaofen Yi¹, Xiangyu Jin², Ying Hu¹

¹Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014 Zhejiang, China.

Molecular pharmaceutics

|September 26, 2025

概括

有效的癌症治疗依赖于药物透到瘤中,这是由瘤微环境 (TME) 阻碍的. 药物输送系统 (DDS) 对于克服这些物理障碍和改善治疗结果至关重要.

科学领域:

在瘤学瘤学.
生物医学工程生物医学工程
药物运输药物运输药物运输

背景情况:

癌症治疗的有效性因药物透到瘤组织而显著受到限制.
瘤微环境 (TME) 中的物理障碍阻碍了药物输送,降低了治疗结果.
关键的TME障碍包括血脑障碍 (BBB),血管障碍,细胞外矩阵 (ECM),间位液压 (IFP) 和固体应力 (SS).

研究的目的:

检查TME物理障碍的特征及其对癌症治疗的影响.
审查旨在克服TME障碍并提高药物透率的药物输送系统 (DDS).
讨论用于DDS用于瘤治疗的纳米材料的挑战和重要性.

主要方法:

对TME物理障碍及其对药物输送的影响的文献综述.
分析各种DDS策略,以克服TME限制.
对用于癌症治疗的临床相关纳米材料的检查.

主要成果:

物理障碍显著限制了毒品的透和分销.
在克服这些障碍以提高药物递送效率方面,DDS显示出有希望.
几种纳米材料已经进入临床试验,证明了潜在的治疗益处.

结论:

了解TME障碍对于开发有效的癌症疗法至关重要.
先进的DDS,特别是使用纳米材料的DDS,对于优化瘤药物透是必不可少的.
需要对DDS进行进一步的研究和开发,以提高癌症治疗的临床结果.

关键词:

癌症治疗疗法癌症治疗药物输送系统是药物输送系统.细胞外矩阵是细胞外矩阵.物理障碍物物理障碍物瘤微环境是一个微环境.

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