在单边核化后对视网母细胞瘤患者的轨道发育进行长期观察
Cancer medicine
|September 26, 2025
概括
视网膜母细胞瘤患者的轨道体积在去核化后3-12个月显示出显著的发展,在手术轨道上出现平原和~5%的赤字. 年龄和植入物类型会影响结果.
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
- 医疗成像医学成像
背景情况:
- 视网母细胞瘤是一种常见的儿科眼癌.
- 单侧核切除是晚期视网膜母细胞瘤的标准治疗方法.
- 轨道发育的差异需要进行研究.
研究的目的:
- 为了研究双边轨道体积发育的差异,在单边无核化后视网膜母细胞瘤患者.
- 确定影响轨道生长和外科手术后发展的因素.
主要方法:
- 北京通仁医院 (2011-2020年) 39名视网膜母细胞瘤患者的回顾性分析.
- 使用ITK-SNAP软件从手术前和手术后影像中重建的双边轨道体积.
- 在多个时间点对轨道体积的比较分析:3个月,1年,3年,以及最终的后续.
主要成果:
- 在手术和非手术方面之间没有显著的手术前轨道体积差异.
- 显著的双边轨道体积差异出现后核化,在12个月达到顶峰.
- 手术轨道显示生长限制,与非手术侧相比,最终体积赤字约为5%.
- 操作时的年龄和轨道植入物类型被确定为影响因素.
结论:
- 轨道发育在去核后3至12个月之间是活跃的,随后是平原阶段.
- 在手术治疗的轨道中观察到一个稳定的~5%的轨道体积赤字.
- 水凝植入物可能会减少体积缺陷,但会带来更高的并发症风险.
相关概念视频
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Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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