在临床实践中Cenobamate的长期有效性和耐受性:一项回顾性观察性研究
Shubhi Agrawal1, Batool A Hussain, Kiran M Kanth
1Department of Neurology, University of California, Davis, USA.
Annals of Indian Academy of Neurology
|September 26, 2025
概括
塞诺巴 (CNB) 提供临床上有意义的抗药性 (DRE) 发作减少至少1.5年. 虽然15%的患者实现了无发作,但由于疗效或副作用,治疗失败很常见.
科学领域:
- 神经学 神经学
- 临床药理学 临床药理学
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 雪诺巴 (CNB) 是一种被批准用于治疗耐药性的抗药物.
- 关键试验和开放标签扩展 (OLE) 表明有效性,但OLE结果可能会被同时治疗混.
- 需要进行扩展的随访,以澄清CNB在DRE中的持续有效性和安全性.
研究的目的:
- 评估青酸 (CNB) 在耐药性 (DRE) 的成年人中长期的疗效和安全性.
- 评估治疗结果,包括发作自由和减少,以及治疗失败的原因.
主要方法:
- 从2020年5月到2023年12月,对60名DRE成年人进行了回顾性研究,他们接受了CNB治疗.
- 收集的数据包括人口统计,史,CNB剂量,发作频率,不良事件和治疗变化.
- 治疗失败被定义为CNB退出或启动另一种治疗.
主要成果:
- 平均随访时间为20.5个月; 56.7%的患者经历了治疗失败 (平均存活时间为17.2个月).
- 15%的参与者实现了无;21%的参与者减少了≥90%的.
- 治疗失败归因于不完全的疗效 (44%) 或不良反应 (38%).
结论:
- 塞诺巴 (CNB) 在患有DRE的患者中至少1.5年表现出临床意义上的疗效.
- 在最后一次随访时,78%的患者接受了持续的CNB治疗.
- CNB为DRE提供了一种可行的治疗选择,尽管应监测疗效和耐受性.
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