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Higher Mental Functions of the Brain: Language01:10

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Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
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改变动态功能网络连接在中风后的失言症中.

Guihua Xu1, Yongsheng Wu1, Junyu Qu1

  • 1Department of Radiology, Qilu Hospital of Shandong University and Qilu Medical Imaging Institute of Shandong University, Jinan, China.

Annals of clinical and translational neurology
|September 26, 2025
PubMed
概括
此摘要是机器生成的。

动态功能网络连接 (dFNC) 分析显示,在中风后失语症 (PSA) 患者中,大脑网络状态发生变化. 动态连接性的这些变化与语言功能相关,这表明dFNC是失语症的潜在生物标志物.

关键词:
默认模式网络模式 默认模式网络模式动态功能网络连接能力 动态功能网络连接语言网络语言网络在中风后的失语症.

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科学领域:

  • 神经科学是一个神经科学.
  • 临床神经学 临床神经学
  • 医疗成像医学成像

背景情况:

  • 以前对中风后失语症 (PSA) 的研究主要使用静态功能连接.
  • 动态功能网络连接 (dFNC) 为PSA中大脑功能提供了一个新的视角.

研究的目的:

  • 为了研究PSA患者dFNC的变化.
  • 探索dFNC和临床语言结果之间的关系.

主要方法:

  • 招募了40名PSA患者和41名健康对照 (NC).
  • 使用休息状态功能磁共振成像 (rs-fMRI) 和西部失言症电池 (WAB).
  • 应用独立组件分析 (ICA) 和移动窗口技术进行dFNC分析,然后进行k-means集群.

主要成果:

  • 确定了4个不同的dFNC状态.
  • 在特定状态下,PSA患者表现出语言内网络 (LN) 连接性减少和网络间连接性改变 (例如,小脑网络 (CN) 和默认模式网络 (DMN)).
  • 模块化网络状态中的dFNC指标与WAB分数相关联.

结论:

  • 改变的dFNC模式是PSA的特征.
  • 在PSA中,dFNC可以作为语言障碍的敏感生物标志物.
  • 这些发现对PSA的诊断评估和治疗计划有影响.