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关于维奥拉耶多尼斯和莱昂纳鲁斯日本对牛子宫内膜炎的治疗效果的研究

Xuewen Tan^1,2, Xingchen Wang^1,2, Nishang Liu^1,2

¹College of Veterinary Medicine, Northwest A&F University, Yangling 712100, P. R. China.

Journal of animal science

|September 26, 2025

概括

传统的中国医学,维奥拉yedoensis和Leonurus japonicus (TCMF),有效地治疗乳牛子宫内膜炎. 这项研究证明了TCMF.

科学领域:

兽医医学兽医医学兽医医学
动物生殖健康动物生殖健康
药理学药理学是指药理学的学科.

背景情况:

乳牛的子宫内膜炎对动物生殖健康构成重大挑战.
目前对子宫内膜炎的抗生素治疗有病原体耐药性和药物残留的风险.
传统中国医学为治疗牛子宫内膜炎提供了一个有希望的替代方案.

研究的目的:

为了研究维奥拉·耶多恩西斯 (Viola yedoensis) 和莱昂努鲁斯·日方 (Leonurus japonicus) (TCMF) 对奶牛子宫内膜炎的治疗效果.
阐明TCMF在治疗子宫内膜炎中的作用的潜在机制.
评估TCMF作为传统抗生素治疗的潜在替代方案.

主要方法:

已建立的LPS诱导的细胞炎症和大鼠子宫内膜炎模型来评估抗炎和治疗作用.
利用质谱和网络药理学来探索TCMF的作用机制.
对乳母牛进行了临床观察,以评估治疗疗效.

主要成果:

在体外和体内,TCMF显著降低了促炎性细胞因子 (IL-1β,IL-6,IL-8,IL-18).
在老鼠模型中,TCMF降低了子宫指数,细菌负载和炎症标志物.
临床试验显示,TCMF改善了子宫排泄分数,降低了PMN和细菌负载,在奶牛中实现了80%的治愈率,随着白蛋白和超氧化物脱酶水平的增加.

结论:

维奥拉yedoensis和Leonurus japonicus (TCMF) 在乳牛子宫内膜炎上表现出显著的治疗作用.
至少部分地,TCMF通过TNF信号通路发挥其治疗作用.
在治疗牛胎内膜炎方面,TCMF为抗生素提供了可行的替代方案,有可能减轻耐药性和残留问题.

关键词:

狮子 (Leonurus japonicus) 是一个日本.维奥拉耶多尼斯 (Viola yedoensis) 是一种植物.在子宫内膜炎中,子宫内膜炎是什么?这是一种炎症炎症炎症炎症.网络药理学网络药理学

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