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多参数动态对比成像用于对脑瘤的量化评估

Yang Chen^1,2,3, Jiayu Xiao^1,3, Steven Cen¹

¹Department of Radiology, Keck School of Medicine, University of Southern California, 2250 Alcazar St, CSC Rm 104, Los Angeles, CA 90033.

Radiology. Imaging cancer

|September 26, 2025

概括

一种新的多参数动态对比成像 (mpDYCI) 技术允许同时量化脑瘤特征,包括 perfusion 和 permeability. 这种先进的MRI成像方法提供了全面的声音评估,改善了脑瘤的特征.

科学领域:

放射学和医学成像学医学成像学
神经瘤学神经瘤学
生物物理学的生物物理.

背景情况:

准确的脑瘤特征对于有效的治疗规划和监测至关重要.
目前的成像技术可能无法提供关于瘤微环境的全面的量化数据.
多参数评估可以揭示内异质性,并区分瘤进展与治疗效应.

研究的目的:

开发和验证一种多参数动态对比成像 (mpDYCI) 技术,用于同时量化脑组织输液,微血管透性,跨膜水流量和敏感性.
为了使脑瘤的多方面的定量评估能够被整合到常规成像协议中.
探索mpDYCI在表征脑瘤和区分治疗相关影响方面的临床实用性.

主要方法:

对mpDYCI技术的前性评估,使用基于MR多任务动态T1和T2*映射方法.
将技术优化纳入脉冲序列,图像重建和量化,以进行强大的全脑多参数分析.
在数字幻象和体内实验中使用类内相关系数 (ICC) 评估间歇重复性和准确性,对健康参与者和脑瘤患者进行实验.

主要成果:

来自mpDYCI的定量指标显示出良好的到出色的重复性 (ICC ≥0.80) 和准确性 (≤15.21%的误差).
mpDYCI成功捕获了内异质性,通过组图分析,voxel聚类和组织学验证证实了这一点.
数量指标之间的低音量相关性表明了互补信息,mpDYCI显示了区分治疗效果与脑转移中的瘤进展的潜力.

结论:

开发的mpDYCI技术可以在一次7.5分钟的扫描中同时量化 perfusion,permeability,水流量和易感性.
这种方法提供了脑瘤的综合性表征,提供了补充的多参数信息.
mpDYCI有望在脑瘤成像协议中进行常规集成,以提高诊断能力.

关键词:

脑瘤的异质性脑瘤的异质性大脑/大脑干在CNS中,CNS是CNS.动态对比增强MRI的动态对比增强.动态敏感性对比MRI磁共振成像在MR成像中使用MR成像.在 MR perfusion 中使用.MR动态对比增强的增强对比多参数MR成像技术量化敏感性映射量化敏感性映射重建算法重建的算法瘤免疫微环境

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