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Updated: Jul 31, 2026

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
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使用hESC衍生的脑器官模型模拟同核病变

So Jin Kim1, Won Hee Jung1, Mu Seog Choe2

  • 1Department of Molecular Physiology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Vessel-Organ Interaction Research Center (VOICE, MRC), Kyungpook National University, Daegu 41566, Republic of Korea.

Cells
|September 26, 2025
PubMed
概括

研究人员使用SNCA基因突变开发了一种人类大脑器官模型,用于合成核蛋白病变. 这种模型显示了疾病的关键特征,并且对于测试向α-synuclein聚合的药物非常有用.

关键词:
大脑的有机体疾病建模 疾病建模药物测试试验 药物测试试验是药物测试.人类多能干细胞干细胞综核蛋白异常症 (synucleinopathy) 是一种同核蛋白异常症.

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