Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Surface Membrane Barriers01:18

Surface Membrane Barriers

2.6K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.6K
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

1.4K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.4K
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

770
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
770
Physiological Barriers01:25

Physiological Barriers

5.0K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.0K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

9.6K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
9.6K
Introduction to the Integumentary System01:25

Introduction to the Integumentary System

13.0K
The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
13.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Atomic Visualization of Surface Photovoltage Effect on Si(111)-(7 × 7) with Gated Integrating Laser-Combined Scanning Tunneling Microscopy.

The journal of physical chemistry letters·2026
Same author

Correlated evolution of core skin structures in freshwater fishes and challenges to epidermal club cells as the material basis of alarm responses.

Frontiers in zoology·2026
Same author

Acoustic Cavitation-Induced Unfolding and Solubilization of Velvet Antler Protein for Antioxidant Peptide Release: Substrate Modification Kinetics, Quantum Chemistry, and Keap1/Nrf2-Associated Cellular Responses.

Ultrasonics sonochemistry·2026
Same author

Kinematics of different vault techniques in elite male gymnasts.

Scientific reports·2026
Same author

Signaling pathways related to interstitial cystitis.

Frontiers in immunology·2026
Same author

How Time Pressure Amplifies Framing Effects in Risky Decision-Making: The Role of Attentional Allocation and Information Presentation.

Behavioral sciences (Basel, Switzerland)·2026

相关实验视频

Updated: Jan 16, 2026

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

4.8K

皮肤屏障:一个由相位分离驱动的系统

Fengjiao Yu1, Lu Leng1, Haowen Wang1

  • 1College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.

Cells
|September 26, 2025
PubMed
概括
此摘要是机器生成的。

皮肤屏障的形成是由液-液相分离 (LLPS) 协调的,从而产生结构和信号凝结物. 这一过程对于皮肤健康和了解诸如亚托皮炎等疾病至关重要.

关键词:
河马的路径 河马的路径在RIPK4中使用RIPK4.亚托邦性皮肤炎的发生.角质灭症是指角质灭症.菲拉格林 (Filaggrin) 是一个基拉托亚林颗粒是基拉托亚林颗粒.液态液态相隔离器 液态液态相隔离器皮肤障碍物 皮肤障碍物

更多相关视频

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue
06:20

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

1.5K
Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

12.9K

相关实验视频

Last Updated: Jan 16, 2026

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
06:30

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

4.8K
Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue
06:20

Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

Published on: February 16, 2024

1.5K
Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

12.9K

科学领域:

  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.
  • 皮肤病学 皮肤病学

背景情况:

  • 哺乳动物的表皮提供了一个重要的屏障,防止环境因素和脱水.
  • 传统的"和砂"模型解释了角层的形成,但最近的发现强调了细胞内液体-液体相分离 (LLPS) 作为一个动态机制.
  • 颗粒层的生命周期和角质细胞末端的分化是皮肤屏障功能的关键.

研究的目的:

  • 建议颗粒层生命周期由LLPS来管理.
  • 综合证据支持LLPS在角质素颗粒 (KG) 的形成和功能.
  • 将皮肤屏障疾病重新定义为异常阶段行为障碍.

主要方法:

  • 在皮肤生物学中对LLPS现有的文献进行审查和综合.
  • 对菲拉格林 (FLG) 和RIPK4在凝结物形成中的作用的分析.
  • 通过异常的生物分子凝聚物行为透视镜重新解释遗传性皮肤疾病.

主要成果:

  • 克拉氨酸颗粒 (KGs) 被识别为由费拉格林 (FLG) 阶段分离形成的生物分子凝聚物.
  • 在LLPS中,KG的组装,成熟和溶解都由LLPS主导,从而导致状细胞平坦化 (角质亡).
  • 一个RIPK4-介导的LLPS通路激活Hippo通路,促进分化和皮肤屏障的形成.

结论:

  • 在皮肤屏障形成过程中,LLPS是推动结构和信号过程的基本机制.
  • 生物分子凝聚物的异常相位行为是亚托皮性皮肤炎,常见性 Ichthyosis 和 Bartsocas-Papas 综合征等疾病的基础.
  • 这一框架通过生物物理知情设计,为皮肤生物学和潜在的治疗点提供了新的见解.