皮肤屏障:一个由相位分离驱动的系统
Fengjiao Yu1, Lu Leng1, Haowen Wang1
1College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.
Cells
|September 26, 2025
概括
皮肤屏障的形成是由液-液相分离 (LLPS) 协调的,从而产生结构和信号凝结物. 这一过程对于皮肤健康和了解诸如亚托皮炎等疾病至关重要.
科学领域:
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
- 皮肤病学 皮肤病学
背景情况:
- 哺乳动物的表皮提供了一个重要的屏障,防止环境因素和脱水.
- 传统的"和砂"模型解释了角层的形成,但最近的发现强调了细胞内液体-液体相分离 (LLPS) 作为一个动态机制.
- 颗粒层的生命周期和角质细胞末端的分化是皮肤屏障功能的关键.
研究的目的:
- 建议颗粒层生命周期由LLPS来管理.
- 综合证据支持LLPS在角质素颗粒 (KG) 的形成和功能.
- 将皮肤屏障疾病重新定义为异常阶段行为障碍.
主要方法:
- 在皮肤生物学中对LLPS现有的文献进行审查和综合.
- 对菲拉格林 (FLG) 和RIPK4在凝结物形成中的作用的分析.
- 通过异常的生物分子凝聚物行为透视镜重新解释遗传性皮肤疾病.
主要成果:
- 克拉氨酸颗粒 (KGs) 被识别为由费拉格林 (FLG) 阶段分离形成的生物分子凝聚物.
- 在LLPS中,KG的组装,成熟和溶解都由LLPS主导,从而导致状细胞平坦化 (角质亡).
- 一个RIPK4-介导的LLPS通路激活Hippo通路,促进分化和皮肤屏障的形成.
结论:
- 在皮肤屏障形成过程中,LLPS是推动结构和信号过程的基本机制.
- 生物分子凝聚物的异常相位行为是亚托皮性皮肤炎,常见性 Ichthyosis 和 Bartsocas-Papas 综合征等疾病的基础.
- 这一框架通过生物物理知情设计,为皮肤生物学和潜在的治疗点提供了新的见解.
相关概念视频
Surface Membrane Barriers
2.6K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.6K
Cellular Membranes and Drug Transport
1.4K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.4K
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
770
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
770
Physiological Barriers
5.0K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.0K
Asymmetric Lipid Bilayer
9.6K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
9.6K
Introduction to the Integumentary System
13.0K
The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
13.0K


