星球细胞和星球细胞衍生的细胞外导管在阿片类药物介导的神经疾病中
Sudipta Ray1, Souvik Datta2, Arnab Saha1
1Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Cells
|September 26, 2025
概括
阿片类药物使用障碍会通过星球细胞及其细胞外囊泡 (EV) 引起脑损伤. 这些天体细胞衍生的EV (ADEV) 传播神经炎症和突触功能障碍,为阿片类药物诱导的神经损伤提供了新的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类药物使用障碍 (OUD) 是一个具有重大神经后果的全球健康危机.
- 研究传统上集中在神经元上,但星体细胞及其细胞外囊泡 (EV) 在阿片类神经病理学中越来越被认可.
研究的目的:
- 通过各种阿片类药物对阿片类药物诱导的神经病理学中星球细胞和星球细胞衍生的EVs (ADEVs) 的机制性作用进行审查.
- 探索ADEVs作为潜在的生物标志物和OUD相关神经障碍的治疗点.
主要方法:
- 关于阿片类药物对星球细胞和ADEVs的影响的临床前模型和体外研究的审查.
- 对不同类阿片类药物 (吗啡,海洛因,芬太尼等) 的天体细胞反应和ADEV货物概况的分析. ) 的情况.
主要成果:
- 阿片类药物破坏了天体细胞平衡,导致携带神经毒素载荷的电动汽车释放.
- ADEVs传播神经炎症,损害血脑屏障的完整性,并加剧突触功能障碍.
- 观察到药物特定的ADEV概况,影响微质功能和神经元活力.
结论:
- 星球细胞和ADEV在阿片类药物诱导的脑损伤中发挥着关键作用,推进了神经质模式.
- 在OUD中,ADEV被认为是神经病理的生物标志物和中介物.
- 准星细胞-EV信号通路是缓解神经损伤的有希望的治疗策略.
相关概念视频
01:25Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
01:22Opioid Receptors: Overview
4.1K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
4.1K
01:15Drug Abuse and Addiction: Pharmacological Phenomena
1.1K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.1K
01:26Neurochemical Transmission: Sites of Drug Action
3.4K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.4K
01:04Glial Cells
93.2K
Overview
93.2K
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
782
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
782