Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction01:16

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry01:28

Diels–Alder Reaction Forming Cyclic Products: Stereochemistry

The Diels–Alder reaction is one of the robust methods for synthesizing unsaturated six-membered rings. The reaction involves a concerted cyclic movement of six π electrons: four π electrons from the diene and two π electrons from the dienophile.
Diels–Alder Reaction: Characteristics of Dienes01:29

Diels–Alder Reaction: Characteristics of Dienes

The Diels–Alder reaction brings together a diene and a dienophile to form a six-membered ring. Both components have unique characteristics that influence the rate of the reaction.
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry01:29

Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Advances in semiconductor materials and device architectures for biomedical systems: a mini review.

Biomedical engineering letters·2026
Same author

2-Methoxystypandrone from <i>Polygonum cuspidatum</i> Rejuvenates Senescence by Reducing Mitochondrial ROS.

Antioxidants (Basel, Switzerland)·2026
Same author

Rapid ecotoxicity and genotoxicity assessment using <i>Macropodus ocellatus</i> cells.

Toxicological research·2026
Same author

Vagal blood volume receptors compensate for haemorrhage and posture change.

Nature·2026
Same author

Vagal volume receptors in the heart compensate for blood loss and posture change.

bioRxiv : the preprint server for biology·2026
Same author

Vitisin B rejuvenates senescence via WBP2NL regulation.

Mechanisms of ageing and development·2026

相关实验视频

Updated: Jun 23, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.9K

基于CMC的可注射水凝通过Diels-Alder化学交叉连接,用于伤口愈合应用.

Israr Ali1, Urwa Shahid2, Seon-Hwa Kim2

  • 1Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.

Gels (Basel, Switzerland)
|September 26, 2025
PubMed
概括

由碳氧甲基纤维素 (CMC) 制成的新型注射水凝为慢性伤口愈合提供了一个有前途的解决方案. 这些生物相容和抗菌水凝提供持续的药物释放,改善组织再生.

关键词:
碳甲基纤维素的碳甲基纤维素.库尔库明是一种黄素.药物释放释放药物释放药物释放的时间可以注射的水凝.伤口愈合 伤口愈合

更多相关视频

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
08:05

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

19.9K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.7K

相关实验视频

Last Updated: Jun 23, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.9K
Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
08:05

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

19.9K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.7K

科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 伤口愈合技术 伤口愈合技术

背景情况:

  • 慢性伤口带来了重大的医疗保健挑战,原因是受损的愈合和传统治疗的局限性.
  • 现有的伤口护理方法在药物输送,组织整合,感染控制和患者舒适性方面往往不足.
  • 可注射水凝为局部伤口治疗提供了一种最少的侵入性方法,符合复杂的伤口几何形状.

研究的目的:

  • 开发和表征基于碳甲基纤维素 (CMC) 的新型注射水凝,用于慢性伤口愈合.
  • 评估水凝的凝性质,物理化学特性,机械强度和药物释放动力学.
  • 评估开发的水凝的体外生物相容性和抗菌疗效.

主要方法:

  • 碳氧甲基纤维素 (CMC) 与 furan 组 (45%) 功能化,并通过 Diels-Alder 点击化学与 bismaleimide 交叉连接器交叉连接.
  • 可以注射的水凝是在生理条件下形成的,凝时间被量化.
  • 评估了黄素的物理化学特性,机械强度和持续释放.
  • 使用NIH3T3纤维细胞和对大肠杆菌的抗菌试验进行了体外生物相容性测试.

主要成果:

  • 在生理条件下,基于CMC的水凝表现出快速凝 (<490秒).
  • 水凝表现出有利的物理化学和机械性能,适合伤口应用.
  • 观察到黄素持续释放,大约80%在5天内释放.
  • 在体外研究证实了与纤维细胞的良好生物相容性和对大肠杆菌的显著抗菌活性.

结论:

  • 开发的基于CMC的可注射水凝显示出作为先进的伤口愈合材料的巨大潜力.
  • 水凝提供局部,持续的药物输送,生物相容性和抗菌性质.
  • 这些发现支持使用这些新型水凝来应对慢性伤口管理的挑战.